EFFECT OF SINGLE-DOSE DEXMEDETOMIDINE DURING EXTUBATION ON HEMODYNAMICS, COUGHING AND POSTOPERATIVE SHIVERING A PROSPECTIVE CLINICAL STUDY

Abstract

Extubation is usually associated with an undesirable increase in hemodynamics. Dexmedetomidine has shown to provide smooth and hemodynamically stable emergence. This study was to assess the effect of single-dose dexmedetomidine during extubation on hemodynamics, coughing and postoperative shivering Material and Methods: A prospective, clinical study was conducted among patients aged 40-75 years for elective surgery under general anesthesia. A total of sixty patients were assigned randomly into two groups 30 patients in group A (received 0.5 μg/kg dexmedetomidine) and 30 patients in Group B (received 100 ml of isotonic solution) ten minutes before the end of the surgery, both given over 10 minutes. For grading of coughing and post-operative shivering 4-point scale and 5-point scale were used respectively. Results: Heart rate in the dexmedetomidine group, decreased after administration of the drug at 1-, 3-, 5-, and 10- minutes. After extubation HR increased at 1- and 3- minutes but this increase was signicantly less than the normal saline group. There was a decrease in HR before extubation in the dexmedetomidine group, but after extuabtion, the incidence of coughing and shivering is less in group A than in group B subjects. Conclusion: It can be concluded that dexmedetomidine 0.5/μg/kg administered 10 minutes before the end of the surgery, was attenuated hemodynamic responses to extubating and signicantly reduced the incidence of coughing and postoperative shivering in patients.