A RANDOMIZED CONTROL STUDY COMPARING EMERGENCE CHARACTERS OF DESFLURANE WITH HALOTHANE IN PAEDIATRIC PATIENTS UNDERGOING GENERAL ANAESTHESIA.

Abstract

Background: Emergence agitation (EA) was described at rst by Eckenhoff et al in the early 1960s. EA has been described as a dissociated state of consciousness in which the child is inconsolable, irritable, uncooperative, typically thrashing, crying, moaning or incoherent. Although EA is usually self-limited and occurs within the rst 30-minutes of recovery in PACU, but it can last up to 2 days and lead to physical damage, disconnection of intravenous catheters, removing of dressing or drainage tube and monitoring devices. Although, numerous medications have been studied to prevent or reduce EA in children, no special preventive method has been shown to be highly superior. Aims and objectives: The aim of this study is to compare the emergence characters of Desurane with Halothane. The primary objective is to compare the Emergence characters using PAED (Pediatric Anaesthesia Emergence Delirium) score. The secondary objective is : 1) To compare the recovery characters(Time to recover) using Steward Recovery Scores. 2) To compare the PACU discharge criteria meeting time with Modied Aldrete Score. 3) To assess post operative Pain, nausea, vomiting, shivering. Materials and Methods: This Randomized interventional study (single blinded) was conducted in Institute of child health and hospital for children, egmore from October 2019 to December 2019. 70 Pediatric patients based on the parent article, Comparison of Emergence and Recovery characteristics of Sevourane, Desurane, and Halothane in Pediatric Patients undergoing General Anaesthesia, authored by Welborn ,Hannallallah Published AnesthAnalg. 1996 Nov;83(5):917-20. Result: Recovery time, Emergence Agitation, Time to reach discharge criteria and post operative complications were compared. Post anaesthesia Emergence Agitation was higher in Desurane group compared to Halothane group which was statistically signicant. Desurane resulted in faster recovery, early Emergence than Halothane which was statistically signicant. This is due the fact that Desurane has very low Blood Gas Solubility index which results in rapid emergence and thus Emergence Agitation. Though time to reach discharge criteria was not much prolonged in Halothane group, study showed statistically signicant difference between two groups. Post operative complications is not statistically signicant between two groups. Conclusion: In our study Post anaesthesia Emergence Agitation was signicantly higher in Desurane group compared to Halothane group. Desurane anaesthesia resulted in rapid Emergence, early recovery compared to Halothane anaesthesia .