Affiliation:
1. Assistant Professor, Department of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka
2. Professor, Department of Pathology, Sri Siddhartha Medical College, Tumkur, Karnataka
Abstract
Background: The introduction of the Pap test as a screening procedure to detect precancerous lesions has helped to reduce both the incidence and
mortality of cervical cancer. In order to improve the sensitivity, specicity of the Pap test there has been a shift from conventional cytology to
Liquid based cytology. A disadvantage of the Liquid based cytology is the high cost automated processing equipment. On the other hand, Manual
Liquid-Based Cytology is a technique that also enables cells to be suspended in a monolayer similar to Liquid based cytology and improves
detection of precursor lesions, specimen adequacy and also a cost effective strategy in limited resource setting. To compare the Objective:
diagnostic utility of Manual liquid-based cytology versus Conventional pap smear in cervical cancer detection on cervical smears. Materials and
Methods: In this prospective comparative study, 210 samples were collected for conventional pap smears and Manual Liquid-Based Cytology to
compare the two methods and to correlate with histopathological diagnosis where specimen was available. The Manual Liquid-Based Results:
Cytology showed sensitivity of 100% , specicity of 91.7% while conventional smears had sensitivity of 75% and specicity of 85.7%.The
diagnostic accuracy of Manual Liquid-Based Cytology was 98% and that of conventional method was 78% The p value was less than 0.005 in
Manual Liquid-Based Cytology (0.0001) and CPS (0.0001) methods considering histopathology as gold standard. This study Conclusion:
showed that Manual Liquid-Based Cytology has a higher sensitivity and specicity than conventional pap smears.
Subject
Biomedical Engineering,Applied Microbiology and Biotechnology,Bioengineering,Biotechnology,Biotechnology,Molecular Biology,Bioengineering,Biotechnology,Management, Monitoring, Policy and Law,General Energy,Renewable Energy, Sustainability and the Environment,Applied Microbiology and Biotechnology,Biotechnology,Molecular Medicine,Applied Microbiology and Biotechnology,General Medicine,Management, Monitoring, Policy and Law,Biotechnology,General Medicine,Biotechnology,Bioengineering,Applied Microbiology and Biotechnology,Biotechnology,Applied Microbiology and Biotechnology,Biotechnology,Applied Microbiology and Biotechnology,Biochemistry
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