“TO STUDY PATTERN OF DRUG USE AND SAFETY OF MEDICATION USED IN LIVER DISEASE PATIENT AT TERTIARY CARE TEACHING HOSPITAL.”

Abstract

Background and objectives: Liver disease is one of the major non communicable diseases which leads to change inpharmacokinetics of many drugs requiring monitoring and dose adjustment to improve the efcacy and safety of the patients. Hence present study is undertaken to evaluate the drug usage pattern and its safety prole in liver disease patients. Patients and method:An observational and cross-sectional study was conducted in department of medicine in a tertiary care teaching hospital from January 2020 to January 2021 after getting approval from ethics committee. All the 100 patients including male and female (age group ≥ 12 years) diagnosed with liver disease were included. Demographic data, clinical details, drugs prescribed, WHO prescribing core indicators and adverse drug reactions were analyzed using descriptive statistics. Results: Non-alcoholic fatty liver disease was the most common form of liver disease seen in the study population (n=100). Males (74%) between age group 41-50 years were more prone to liver disease. Average number of drugs prescribed was 8.17 and 77% patients received antibiotics. Gastroprotectives were more mostly prescribed class of drugs (23.9%) followed by antibiotics (17.25%). Among the antibiotics cefotaxime was highly prescribed (79%) followed by metronidazole (32%). Majority of adverse drug reactions reported were due to the antibiotics like diarrhea, nausea, skin rashes and AKT induced hepatitis. Conclusions:As liver is the principal organ for metabolism of many drugs, possible disease -drug interaction may follow with indiscriminate use of many drugs.