A RANDOMIZED STUDY COMPARING THE EFFICACY AND SAFETY OF TWO DIFFERENT BOLUS DOSES OF OXYTOCIN DURING CAESAREAN DELIVERY
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Published:2022-10-01
Issue:
Volume:
Page:74-77
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ISSN:
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Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
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language:en
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Short-container-title:ijsr
Author:
R Nayak Shruthi1, Kumar Karthik1, Nayak Gopalakrishna2, S Rao Gurudutt3, Prasanth B Krishna4
Affiliation:
1. Senior Resident, Department of Anaesthesiology, Yenepoya Medical College, Deralakatte, Karnataka 2. Consultant Anaesthesiologist, NMC Speciality Hospital, Al Ain. 3. Professor, Department of Anaesthesiology, AJ Institute of Medical Sciences, Karnataka 4. Assistant Professor & Epidemiologist, Department of Community Medicine, Sree Balaji Medical College & Hospital, Bharath Institute of Higher Education & Research, Chennai.
Abstract
Background: Typically, oxytocin is used to induce uterine contractions during caesarean delivery. The intravenous administration of oxytocin is
known to have negative side effects, including tachycardia, hypotension, and alterations in electrocardiograms (EKGs), which can be harmful in
high-risk patients. In this study, we contrasted the outcomes of two oxytocin dosages. Methods: A total of 70 patients—35 in each group—were
receiving an I.V. bolus of 2 or 5 units of oxytocin while undergoing elective caesarean sections under spinal anaesthesia. An hourly infusion of ve
units of oxytocin was then administered. Evaluation of uterine tone, the need for further uterotonic drugs, changes in hemodynamics, and adverse
pharmacological effects were compared between the two groups. Results: The two groups' patients had similar characteristics. At two minutes,
uterine tone ratings remained similar. The difference between the two groups at the fth minute was statistically signicant. At the fth minute,
there was a substantial change in the clinically acceptable uterine tone measured over the entire trial time. At the rst minute, the percentage rise in
the mean maternal HR was observed to differ signicantly (p=0.002). No signicant difference in maternal tachycardia existed across the groups.
When the systolic blood pressure was compared to the baseline at 1, 2, 3, 4, 15, 18, and 21 minutes, there was a discernible difference in the percent
drop. There was a noticeable difference in the diastolic blood pressure during the entire trial period. Only few cases had side effects like nausea and
vomiting, there was no appreciable difference. Conclusion: In healthy adult women having an elective caesarean section, a 2-unit oxytocin bolus
followed by an infusion of 5 units per hour had a positive effectiveness and safety prole.
Publisher
World Wide Journals
Subject
Clinical Biochemistry,Molecular Biology,Molecular Medicine,Biochemistry,Clinical Biochemistry,Molecular Biology,Pathology and Forensic Medicine,Cancer Research,Immunology and Microbiology (miscellaneous),General Medicine,Cell Biology,Toxicology,General Medicine,Pathology and Forensic Medicine,Cognitive Neuroscience,Neuroscience (miscellaneous),General Veterinary,General Biochemistry, Genetics and Molecular Biology,Animal Science and Zoology,General Medicine,Space and Planetary Science,Astronomy and Astrophysics,General Biochemistry, Genetics and Molecular Biology,General Neuroscience,Cell Biology
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