ANTIOXIDANT CAPACITY IN PATIENTS WITH ORAL LICHEN PLANUS AND HEALTHY SUBJECTS-A COMPARATIVE STUDY

Abstract

BACKGROUND AND AIM: Oral lichen planus is a common chronic inammatory disease of the oral mucosa with malignant potential. There are various antioxidant systems in body uid which can neutralize the reactive species. Impaired function of these systems leads to oxidative damage in the tissues and can result in the inappropriate activation of the immune system.Thus reduced antioxidant defense and increased oxidative stress may play an important role in etiology of many chronic immune mediated diseases such as: diabetes, psoriasis, vitiligo. Analyzing the antioxidant capacity in patients with OLP is of signicant value as it can provide essential clues in the etiology of the diseases and help in better management of the disease.This study aimed to assess and compare the antioxidant capacity of oral lichen planus patients and healthy subjects. MATERIALS AND METHODS:This study included 50 oral lichen planus patients and 50 healthy subjects . DPPH Assay is used to assess the antioxidant capacity in OLP patients and healthy subjects. The percentage scavenging of DPPH radical gave the antioxidant activity of the sample. RESULTS:Antioxidant level were reduced in the OLP group while comparing it with the control group. Mean antioxidant level in OLP group was 0.6 and that of the control group was 1.6. Comparison of mean antioxidant levels between the OLP group and control group showed signicant (p<0.0001) difference. The difference between the reticular and erosive OLP group showed signicant difference with p value less than 0.0001. CONCLUSION:Antioxidant level signicantly decreased in OLP group compared to control group.Erosive OLP patients show low antioxidant level compared to reticular OLP patients.The ndings of present study support the hypothesis of the association between antioxidant capacity and OLP.