Affiliation:
1. Junior Resident, Department of Radiation Oncology, Govt. Medical College, Thrissur, Kerala
2. Associate Professor, Department of Radiation Oncology, Govt. Medical College, Trivandrum, Kerala
3. Professor and HOD, Department of Radiation Oncology Govt. MedicalCollege, Kannur, Kerala
Abstract
Carcinoma penis is a rare malignancy in males. The World Health Organization Classification of Tumors of the Urinary
System and Male Genital Organs classifies squamous cell carcinoma of the penis into human papillomavirus (HPV) and
non HPV related. Among the HPV-related Squamous cell carcinomas of the penis, clear cell variant is a rare. Here we
report a case of clear cell variant of squamous cell carcinoma of penis with bilateral inguinal lymph node metastasis. We
have treated this patient with radical surgery, wide excision and bilateral inguinal lymph node dissection followed by
post operative chemo radiation. But during radiation itself the disease progressed, with rapid recurrence of inguinal
lymph node metastasis, finally end up with palliative chemotherapy. Clear cell carcinoma is an aggressive form of
cancer, with frequent metastasis to the inguinal lymph nodes, as seen in this case. Immunohistochemistry examination
P16 was absent. So it is considered as clear cell variant of squamous cell carcinoma. Clinical experience with penile
carcinoma is limited because of their rarity.
Subject
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