“ENHANCING TELMESARTAN BY USING SOLID DISPERSION TECHNIQUES”

Abstract

Telmisartan (TLM) is an angiotensin II receptor antagonist used in the treatment of hypertension. Telmesartan (TLM) is an orally active direct-acting Angiotensin1receptor antagonist and possess therapeutic potential in the pharmacotherapy of hypertension. Telmisartan is classified as a class II medicine by the BCS (biopharmaceutical categorization system), and it is nearly insoluble in water, with a low solubility profile and poor absorption. Drugs with poor aqueous solubility are still an ongoing challenge in the successful formulation of therapeutic products due to their low oral bioavailability. Solid dispersions are a dispersion mixture of one or more active ingredients in an inert carrier at the solid state prepared by melting, solvent, solvent-melting or other methods. Cyclodextrins(CDs) with their cylinder-shaped cavities are capable to form inclusion complexes with a wide range of commonly used drugs. Complexation of molecules to CDs occurs through a non-covalent interaction between the molecule and the CD cavity. This is a dynamic process whereby the guest molecule continuously associates and dissociates from the host CD. The present study is to improve the solubility of Telmisartan by solid dispersion techniques using various methods and proved to be effective for further pharmaceutical usage.