ASYMPTOMATIC TRANSIENT SA-NODE CONDUCTION BLOCK IN A PATIENT WITH ACUTE RISPERIDONE+TRIHEXYPHENYDYL TABLET POISONING-Reference-Cited by-同舟云学术

ASYMPTOMATIC TRANSIENT SA-NODE CONDUCTION BLOCK IN A PATIENT WITH ACUTE RISPERIDONE+TRIHEXYPHENYDYL TABLET POISONING

Published:2021-07-15 Issue: Volume: Page:23-24
ISSN:
Container-title:PARIPEX INDIAN JOURNAL OF RESEARCH
language:en
Short-container-title:PIJR

Author:

M C Varun Kumar¹,Meena Shyojiram²,Salvi Dhiresh³,Chaurasiya Pramod⁴

Affiliation:

1. Junior Resident (3 ); Department Of Medicine; GMC Kota.

2. Senior Professor & Unit Head;Department Of Medicine;Gmc Kota.

3. Junior Resident (2 );Department Of Medicine;GMC Kota.

4. Assistant Professor;Department Of Medicine;GMC Kota.

Abstract

BACKGROUND: a case report of 17year old male with acute risperidone + trihexyphenidyl poisoning with transient sinoatrial block without any CNS or neuromuscular complications. CONCLUSION: Risperidone does possess cardiotoxicity as of cardiac conduction abnormalities mainly affecting SA 1 and AV nodes rather than prolongation of QT interval without causing hypotension or myocardial injury . Such a nonlethal conduction aberrancy was observed at a dose of 75mg risperidone was only transient and reversed physiologically without any additional treatment. Further protection from extrapyramidal symptoms was offered by combined drug trihexyphenidyl at cost of sedation.

Publisher

World Wide Journals

Reference3 articles.

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2. Page CB, Calver LA, Isbister GK. Risperidone overdose causes extrapyramidal effects but not cardiac toxicity. J Clin Psychopharmacol. 2010 Aug;30(4):387-90. doi: 10.1097/JCP.0b013e3181e5f7a5. PMID: 20631557.

3. Laroussinie G, Zenut M, Béal M, Bernard C, Lavarenne J. Intoxication aiguë par la rispéridone et perturbations ioniques et électrocardiographiques [Acute poisoning by risperidone and ionic and electrocardiographic changes]. Therapie. 1997 Mar-Apr;52(2):155-6. French. PMID: 9231512.