EFFECT OF VITAMIN C THERAPY ON BURN PATIENTS ON FLUID RESUSCITATION

Abstract

Aims And Objectives:To study the Efficacy of Vitamin C therapy on burn patients. Material And Methods:We enrolled 20adult patients with severe burns (more than 30%) from January 2020 to October 2021 at Plastic Surgery and Burns Hospital, Dhule. Patients with co- morbidities and with pre existing diseases were excluded from the study. Results: Fluid requirement in Group A was 3.74 ± 0.57 ml/kg/% of burns and in Group B was 2.46 ± 0.54 ml/kg/% of burns.Urine output was 1.05 ± 0.28 ml/kg/h in Group A, and in Group B,it was 1.42 ± 0.39 ml/kg/h. Fluid retention and body weight gain were lower in Group B.MDA levels were significantly lower at 36 h in Group B. Discussion:The initial fluid resuscitation in major burn trauma is intravenous infusion of crystalloids solutions to correct hypovolemia and to improve peripheral tissue perfusion.[14] The accepted norms are to monitor the adequacy of resuscitation with urine output of 0.5–1.0 ml/kg/h of body weight and stable hemodynamic status. There have been reports of over resuscitation of burn patients leading to problems such as anasarca,abdominal compartment syndrome, prolonged mechanical ventilation,and pneumonias.This has been termed as “fluid creep”phenomenon. Conclusions: In our study, we found that when high dose Vitamin C (12-15gram) is given as adjuvant therapy in resuscitating the burn patients in the first 48 h,it decreases fluid requirement,increases urine output,and decreases fluid retention in body.