EFFECT OF TIME DOMAIN ON RHEUMATOID ARTHRITIS PATIENTS

Abstract

Rheumatoid arthritis is a chronic multisystem ,a long term ,progressive ,and disabling autoimmune disease of unknown etiology .as the immune system responds ,in inflammation occurs in the target tissue or organ .in the case of RA this can be the joints lungs eyes and heart .Heart rate variability is reliable tool for assessing the activities of autonomic nervous system. In some studies increased heart rate and decreased HRV associated with increased mortality in patients with rheumatoid arthritis. The present study was undertaken to determine the Heart rate variability in rheumatoid arthritis patients and to compare mean valve of time domain SDNN NN50 PNN50 RMSSD Heart rate variability with study group and normal group. MATERIALS AND METHODS: The study was conducted on 50 rheumatoid arthritis patients in the age group of 30- 70years and 50 healthy age and sex matched controls. HRV was done with Medicaid students Physiopac and analyzed with Kubois software Version 2.1. Data was analyzed using statistical software STATA 11.2using ANOVA. Significance of p value was taken as 0.05. RESULT: Data was analyzed using statistical software STATA 11.2using ANOVA. Significance of p value was taken as 0.05. CONCLUSION: In patients with Rheumatoid arthritis time domain frequency is altered. Our findings indicate higher sympathetic activity and higher basal heart rate compared to normal study. An involvement of humoral and cellular immune component has been suggested to play a role in severe autonomic neuropathy