A RARE CASE REPORT OF INVASIVE ASPERGILLOSIS: SUCCESSFULLY TREATED WITH VORICONAZOLE IN IMMUNOCOMPETENT PATIENT

Abstract

14 years old Female with no known co-morbidities reported in Emergency Department with Left periorbital swelling, Breathlessness and Fever since 1 days . Patient desaturated on the next day of admission and was shifted to Medical ICU. HRCT Thorax were done suggestive of multiple variables sized nodular consolidation in bilateral lung parenchyma and perifocal GGOs present. Patient was referred to Ophthalmic and ENT surgeon for an opinion and was advised CT PNS suggestive of iso dense collection in posterior ethmoid sinus,spheno-ethmoid recess & sphenoid sinus.FESS (functional endoscopic sinus surgery) was performed and aspirated fluid was sent for histopathological analysis. Histopathological appearance was suggestive of Aspergillosis.Aspergillus lung nodule with Paranasal sinus involvement in young Female without any risk factor is rare. Patient was managed with Intravenous voriconazole for 10 days followed by Oral voriconazole 200 mg bd for 5weeks.On follow up patient was asymptomatic with no residual swelling.