CASE REPORT: MIXED CONNECTIVE TISSUE DISEASE (MCTD)

Author:

J Patel Hirni1,Panchal Kuldip1,Nayak S P Srinivas2,Buddhadev Mohit2,Chakraborthy G.S.3

Affiliation:

1. Pharm D Intern, Parul Institute of Pharmacy and Research, Parul University, Vadodara,Gujarat.

2. Assistant Professor, Department of Pharmacy Practice, Parul Institute of Pharmacy and Research,Parul University,Vadodara,Gujarat.

3. Professor and Principal, Parul Institute of Pharmacy and Research, Parul University,Vadodara,Gujarat.

Abstract

Background: The term mixed connective tissue disease (MCTD) was coined by Sharp and colleagues in 1972 proving to that mixed connective tissue disease a systemic autoimmune disease which involves antibodies like anti-sm, Ro-52 recombinant, nucleosome,anti-Jo-1,anti ds-DNA,etc. Case presentation: A 28-year-old lady presented with complaints of multiple joint pain since 3 days along with weakness. She also complained about low grade fever associated with chills and rigor, vomiting, headache and body ache. There was involvement of morning stiffness in small joints of fingers and toes. Reports were done and she was eventually treated according to it. Conclusion: The work has reported a rare case of an adult patient with MCTD characterized by a severe multiple joint pain along with severe weakness and positive AntiU1-RNP levels and was treated with corticosteroid (Prednisolone), Methotrexate and analagesic (Tramadol and Paracetamol).

Publisher

World Wide Journals

Reference10 articles.

1. Kim, P. and Grossman, J., 2005. Treatment of Mixed Connective Tissue Disease. Rheumatic Disease Clinics of North America, 31(3), pp.549-565.

2. R.W. Hoffman, Mixed connective tissue disease and overlap syndrome, in: D.J. Wallace, B.H. Hahn (Eds.), Dubois' Lupus Erythematosus, 7th ed., Lippincott Williams and Wilkins, New York, 2007, pp. 975–991.

3. R.W. Hoffman, Overlap syndromes: mixed connective tissue disease and Sjogren's syndrome, in: R.G. Lahita (Ed.), Systemic Lupus Erythematosus, 4th ed., Elsevier, New York, 2004, pp. 717–744.

4. Reichlin, M., and Mattioli, M. (1974). Antigens and anti-bodies characteristic of systemic lupus erythematosus.Bulletin of Rheumatic Diseases, 24, 756-760.

5. Reichlin, M. (1976). Mixed Connective tissue disease, InModern Topics in Rheumatology, ed. G. R. V. Hughes, pp.162-166. Heinemann: London.

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