DOSIMETRIC COMPARISON OF HEART DOSE WITH 3DCRT VS IMRT IN POST-MASTECTOMY LEFT SIDED CHEST WALL IRRADIATION-Reference-Cited by-同舟云学术

DOSIMETRIC COMPARISON OF HEART DOSE WITH 3DCRT VS IMRT IN POST-MASTECTOMY LEFT SIDED CHEST WALL IRRADIATION

Published:2022-02-15 Issue: Volume: Page:5-7
ISSN:
Container-title:PARIPEX INDIAN JOURNAL OF RESEARCH
language:en
Short-container-title:PIJR

Author:

Loyal Anushree¹,Kapoor Tapan²,Sharma Jyoti³

Affiliation:

1. Assistant Professor, Department of Radiation Oncology, Mahatma Gandhi Medical College,Jaipur.

2. Senior Resident, Department of Radiation Oncology, Mahatma Gandhi Medical College,Jaipur

3. Junior Resident, Department of Radiation Oncology, Mahatma Gandhi Medical College,Jaipur.

Abstract

Purpose: Data regarding the efficacy of various radiotherapy techniques for post mastectomy chest-wall radiotherapy (PMRT) using hypofractionation is scarce and cardiac toxicity remains a concern.This study aims to compare effect of IMRT (Intensity Modulated Radiation Therapy) and 3D-CRT (3-Dimensional Conformal Radiation Therapy) techniques on cardiac dose. Materials and Methods: In this retrospective study,we compared IMRT and 3DCRT plans of 20 patients who received PMRT to a dose of 42.56Gy/16# and the dosimetric parameters in terms of planning target volume (PTV) coverage and dose to organ at risk (OARs) including heart and ipsilateral lung were recorded and analyzed. Result: PTV coverage were comparable with both techniques. IMRT planning provided a better conformity index as compared with 3DCRT (0.95 vs 0.91, p<0.001).The mean dose to the heart significantly reduced with IMRT (4.36Gy vs 8.2Gy,p<0.00001). Conclusion: IMRT offers a significant reduction in mean heart dose than 3DCRT in patients treated with hypofractionated post-mastectomy irradiation.

Publisher

World Wide Journals

Reference17 articles.

1. Hyuna Sung, Jacques Ferlay, Rebecca L. Siegel et al. Global Cancer Statistics 2020: GLOBOCAN Estimates of Incidence and Mortality Worldwide for 36 Cancers in 185 Countries.CA CANCER J CLIN 2021;71:209–249

2. Luca F Valle, Surbhi Agarwal et al. Hypofractionated whole breast radiotherapy in breast conservation for early-stage breast cancer: a systematic review and meta-analysis of randomized trials. Breast Cancer Res Treat. 2017;162(3):409-417.

3. Shu-Lian Wang, Hui Fang et al. Hypofractionated versus conventional fractionated postmastectomy radiotherapy for patients with high-risk breast cancer: a randomised, non-inferiority, open-label, phase 3 trial. Lancet Oncology 2019 Mar;20(3):352-360.

4. Sarah C Darby, Marianne Ewertz et al. Risk of ischemic heart disease in women after radiotherapy for breast cancer. N Engl J Med 2013 Mar 14;368(11):987-98.

5. Sardaro A, Petruzzelli MF et al, Radiation-induced cardiac damage in early left breast cancer patients: Risk factors, biological mechanisms, radiobiology, and dosimetric constraints. Radiother Oncol 103(2): 133–142.