“A CLINICOPATHOLOGICAL STUDY OF PROSTATE SPECIMENS AND ITS CORRELATION WITH PROSTATE SPECIFIC ANTIGEN LEVELS''

Abstract

Background: Prostate is fibromusculoglandular organ encircling the neck of the urinary bladder, Benign prostate hyperplasia, prostate carcinoma and prostatitis are three pathologic processes which frequently affect the prostate gland.Prostatic enlargement causes urinary symptoms of static (hesitancy,retention) and dynamic (urgency,dribbling) nature.PSA is a glycoprotein which is expressed by both normal and neoplastic prostate tissue.PSA is used widely as a screening tool for carcinoma prostate.Gleason's microscopic grading is a paramount feature and with PSA are important for diagnosis,management,and prognosis of carcinoma.The purpose of this study is to frame evidence based PSA levels for various prostatic lesions.Method:This prospective study was done on total 50 samples.The samples taken were both transurethral resection of prostate and prostatic biopsies.All were grossed,sectioned,stained using H & E,viewed under microscope and graded by Gleason's scoring. Result:Total 50 samples were studied,out of which 46 were benign and 4 malignant.Mean age of the cases was 63.13 years.8% patients had PSA values more than 20 ng/ml. Conclusion: PSA is specific for prostate and is one of the best screening tools available for early detection of prostate cancer as it is a well accepted, simple, safe and cost effective method. The early diagnosis of clinically significant cancer obtained by evaluation of PSA levels helps in immediate and effective treatment.