“A COMPARATIVE STUDY BETWEEN INTRAVENOUS FENTANYL AND MAGNESIUM SULFATE IN ATTENUATION OF CARDIOVASCULAR RESPONSE TO LARYNGOSCOPY AND ENDOTRACHEAL INTUBATION”

Abstract

Background and Objectives: Laryngoscopy and intubation are associated with stress response leading to hypertension,tachycardia and cardiac arrhythmias.It may be of no consequences in patients with normal cardiovascular status but undesirable in patients with comorbid conditions such as hypertension, coronary artery disease, cerebrovascular disease and thyrotoxicosis etc.Various pharmacological and non-pharmacological methods have been studied in attenuating this response.The present study is undertaken to compare the efficacy of Fentanyl and Magnesium sulphate in attenuating cardiovascular response to laryngoscopy and endotracheal intubation. Methods: A prospective, randomized double blinded study was conducted among 100 ASA I/II adults patients undergoing electives surgeries under general anesthesia. Group A (n=50): received inj. fentanyl (2g/kg) and Group B (n=50): received inj. Magnesium Sulfate 30mg/kg. Heart rate, systolic, diastolic and mean arterial pressure were measured at baseline,before induction,before intubation,just after intubation,3,5,10,15,30 mins after intubation. Results: Fentanyl showed more effective in attenuating the cardiovascular response to laryngoscopy and intubation compared to Magnesium Sulfate Conclusion: IV Fentanyl 2μg/kg is a better drug than Magnesium Sulfate 30mg/kg in controlling cardiovascular response to laryngoscopy and intubation.