Affiliation:
1. Research Scientist,Department of Biotechnology,BarkatullahUniversity,Bhopal (M.P.)462026.
2. Head, Department of Biotechnology,Barkatullah University,Bhopal(M.P.) 462026.
Abstract
Most of the active phytoconstituents under development are poorly water soluble or have poor bioavailability .
Nanotechnology is an approach to overcome the challenges of conventional drug delivery systems and limitations of
phytochemicals. Solid Lipid nanoparticles show interesting features concerning therapeutic purposes. The main
advantage is that they are prepared with physiologically well-tolerated lipids.Solid Lipid Nanoparticles (SLNs) as novel
lipid based nanocarriers with size range between 10 to 1000nm. SLNs were introduced to overcome problems of
polymeric nanoparticles.In present research formulation and evaluation of nanoparticles with ethanolic extract of two
plants Celastrus paniculatus and Bacopa monnieri along with Donepezil as a standard drug was undertaken here for the
production methods for preparation of SLNs, and pharmaceutical approach of SLNs in drug delivery . The focus of
nanoparticle design over the years has evolved toward more complex nanoscopic core–shell architecture using a single
delivery system to combine multiple functionalities within nanoparticles which combine the mechanical advantages of
biodegradable polymeric nanoparticles and biomimetic advantages of liposomes, have emerged as a robust and
promising delivery platform.
Solid liquid nanoparticles having plant extracts were successfully formulated and characterized for their stability.A
biodegradable polymeric core is surrounded by a shell composed of layer(s) of phospholipids. This architecture can
provide advantages such as controllable particle size, surface functionality, high drug loading, entrapment of multiple
therapeutic agents, drug release profile,and good serum stability of phytochemicals