Affiliation:
1. MS, FSSN, Choudhury Eye Hospital & Research Centre, Shyamaprasad Road Shillongpatty ,Silchar,Assam,India
2. MS, Choudhury Eye Hospital & Research Centre, Shyamaprasad Road (Shillongpatty),Silchar,Assam,India
Abstract
Background - Migraine is one of the common causes of recurrent headaches. Botulinum toxin type A (Botox®) is a
neurotoxin produced by Clostridium botulinum that paralyzes nerves. The purpose of this study was to evaluate the
efficacy of pericranial Botox® administration in migraine headache in patients attending a tertiary eye care centre.
Method - A prospective,non-randomized study consisting of 54 patients was performed.Subjects were candidates who
either sought Botox® treatment for hyperfunctional facial lines with concomitant headache or candidates for Botox®
treatment specifically for headaches. Headaches were classified based on International Headache Society criteria.
Botox® was injected into the glabellar,temporal,frontal,and/or suboccipital regions of the head and neck.Patients were
treated every three months,with a maximum of three sessions.Botox dosage ranged from 75 - 155 Units per patient.Main
outcome measures were relief from migraine headache symptoms, reduction of headache severity and duration of
symptom free period. Results - Age ranged from 18 to 65 (mean 34.6±6.5) years. Among 54 subjects treated
prophylactically,complete response (symptom elimination) was noted in 31 (57.40%) with a mean {Standard deviation –
(SD)} response duration of 4.3 (2.4) months; 16 (29.62%) reported partial response (≥50% reduction in headache
frequency or severity) with a mean (SD) response duration of 2.5 (1.7) months. 7 (12.96%) reported no response. No
systemic adverse effects were reported.Conclusion - Botox® is found to be a safe and effective therapy for prophylactic
treatment of migraine.
Subject
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