“STUDY OF PROLIFERATIVE INDICES USING MITOTIC INDEX AND AGNOR AND THEIR CORRELATION WITH VARIOUS GRADES OF BREAST CARCINOMA”

Abstract

Background: Breast cancer is a leading cause of death in women. The objectives of this study were to compare the argyrophilic nucleolar organizer region (AgNOR) count and mitotic index with various histological grades of infiltrating ductal carcinoma of breast. Aim: To study the relationship of the proliferative indices and various grades of breast carcinoma. Objective: "Study of proliferative indices using mitotic index and Agnor and their correlation with various grades of breast carcinoma" Material and Method: In this prospective study all specimens of infiltrating ductal carcinoma of female breast belonging to all age groups received in the department of histopathology of Gajra Raja Medical College,Gwalior during the period of three years were graded using Bloom and Richardson score and correlated with proliferative indices mitotic index and AgNOR counts. Result: The mean Age (Years) was 46.16 ± 8.68.The mean B&R Score was 6.52 ± 1.20.The mean Mitotic Index was 8.51 ± 2.61.The mean AgNOR Count was 4.24 ± 2.34.There was significant correlation between AgNOR count,mitotic index and histological grades. Conclusion: AgNOR count and mitotic index can be used as reliable proliferative indices which correlate well with the histological grades and are cost effective too.