RELATION OF ELEVATED SERUM LIPIDS AND LIPOPROTEIN (A) TO OXIDATIVE STRESS IN PSORIASIS.

Abstract

Background: Psoriasis is a chronic inammatory disease with multisystem involvement. Psoriasis is an immune mediated skin disease characterized by hyperproliferation of keratinocytes9 which is initiated and maintained by inammatory mediators. Objective: To determine the serum lipid disturbances in psoriasis. To assess the signicance of lipoprotein (a) levels in psoriasis. Materials And Methods: 30 Number of cases of patients suffering from Psoriasis in the age group of 15-75 was included in the study.30 age and sex matched healthy volunteers served as controls. Results: Signicant elevation in levels of fasting glucose, creatinine, total cholesterol.triglycrides, VLDL, LDL, Lipoprotein (a), and Malondialdehyde (MDA) was observed in cases compared with controls. Conclusions: It is important to measure serum lipid level particularly cholesterol, LDL and TG in psoriatic patients for early screening of hyperlipidemia to evaluate risk to atherosclerosis and vascular obstructive disorders and its complications.