ANALYSIS OF SERUM PROSTATE SPECIFIC ANTIGEN AFTER TURPAND ITS CORRELATION WITH LEVEL OF COMPLETION IN TURP

Abstract

Patients experience marked decline in serum PSA after TURP; thus PSA behaviour after TURP is crucial during patient follow up. It is known that serum PSA levels increase temporarily in first few days following TURP, decreasing gradually afterwards and reaching stable values within 3-6 months. We conducted study to elucidate fall in serum PSA 3 months after TURP; and also to correlate serum PSA with size of prostate. Methods The study was conducted in Department of Surgery and Urology, Government Medical College, Jammu from November 2016 till date. During this study period, 40 patients who underwent TURP for benign prostatic hyperplasia were enrolled in study. Serum PSA levels were measured preoperatively and 3 months postoperatively. Results The mean decline in serum PSA in benign prostate glands following TURP was 66.06%. Resection of 1% of prostate tissue resulted in 2.23% reduction in PSA and resection of one gram of prostate tissue resulted in mean decrease of 0.13±0.7 ng/ml in PSA. Conclusion There is significant decrease in serum PSA levels after TURP in BPH patients. PSA level after TURP depends on various factors including pre-operative PSA and prostate volume; and prostate volume resected. There is linear relationship between different resection extent of TURP surgery and declination in serum PSA. After complete TURP with benign histopathologic specimen, PSA should be expected to be within normal reference range; mostly near the value of 1ng/ml. Serum PSA should be monitored at 3 months post TURP to assess the extent of resection of prostate.