DIAGNOSTIC UTILITY OF KI 67 IMMUNOSTAINING IN DIFFERENTIATION OF PSORIASIS VS OTHER PSORIASIFORM DERMATITIS

Abstract

BACKGROUND: Psoriasis is a prototype of psoriasiform tissue pattern and needs to be differentiated from other psoriasiform dermatoses(PD)bothclinicallyandhistopathologically. AIM: To study the morphology of psoriasis and other psoriasiform conditions and to study the expression of Ki67 to distinguish psoriasis from the other psoriasiformdermatitislesions. METHODS:Astudywasperformedonparafnblocksof28psoriasis and22psoriasiformdermatitispatientsbetween2018and2020.The selectedformalin xed parafn embedded tissuesfrom each biopsy specimen were cut into 3-5 µm section and were stained with hematoxylin and eosin. Primary antihuman antibodiesagainstki67wereapplied. RESULTS: Out of 50 patients, 62% were men and in the age group of 21-40 years. Mean staining of Ki 67 was higherin psoriasisthan other psoriasiform dermatitis. CONCLUSION:ThepresentstudyshowedtheexpressionofKi67biomarkerhigherinpsoriasisascomparedtotheotherpsoriasiformdermatitislesions.