CLONIDINE 100MCG VERSUS 200 MCG AS THE MAIN STAY FOR CIRCULATORY MANIPULATION IN FUNCTIONAL ENDOSCOPIC SINUS SURGERY: A RANDOMISED COMPARATIVE STUDY

Abstract

Background: Functional endoscopic sinus surgery (FESS) is most widely recognized surgery done for management of chronic sinusitis. The aim of this study was to compare the optimization of operating conditions produced by either 100 μg or 200 μg oral tablet clonidine as the mainstay for circulatory manipulation during Functional Endoscopic Sinus Surgery. Method: A double-blind randomized comparative study was done in 60 cases divided into two groups. Group 1(n=30) patients were given 100 μg tablet clonidine; group 2(n=30), patients were given 200 μg of tablet clonidine orally 1 hour 30 minutes before surgery with 75ml water. Hemodynamic monitoring (HR, NIBP, SBP, DBP, MAP, SPO , ETCO ). Quality of bloodless surgical eld created intraoperatively was assessed2 2 by Fromme-Boezzart scale, Likert's scale at the end of procedure. Postoperatively, patients were assessed using Brussel's sedation score, and adverse effects like Bradycardia, Somnolence, Delayed recovery were recorded. Result: No statistically signicant difference seen in age, weight, gender, and ASA grading in both groups. Comparison of quality of surgical eld created, assessment through Fromme-Boezzart grading system and Surgeon's satisfaction using Likert scale between both the groups was not statistically signicant between the groups (P-value >0.05). We infer that both doses of clonidine tablets were equally effective in creating bloodless surgical eld. Conclusion: Non inferiority of 100microgram oral clonidine compared with 200 microgram oral clonidine for induction of hypotension during FESS surgery with less side effects and creating an intraoperative blood less surgical eld.