A STUDY ON EXPRESSION OF P16 AS A SURROGATE MARKER OF HIGH RISK HPV INFECTION IN OROPHARYNGEAL, HEAD & NECK SQUAMOUS CELL CARCINOMA & ITS CORRELATION WITH DIFFERENT HISTOMORPHOLOGICAL FEATURES

Abstract

Aim of this study is to assess the expression of p16 as an immunohistochemical marker (which is a predictor or surrogate marker of high risk HPV infection) in oropharyngeal, head and neck squamous cell carcinoma and its correlation with different histomorphological features. Our study was an observational, descriptive study with cross-sectional design, done in the Department of Pathology, in collaboration with the Department of Plastic Surgery. It was conducted on a group of patients admitted in Department of plastic Surgery, R G KarMedical College & Hospital, and Kolkata. The samples included 54 specimens of, oropharyngeal & head neck SCC. Here, in this study, the expression of P16 in oropharyngeal & head neck SCC was shown& correlated with their histomorphological features. In present study median age of p16 positive patients were 54 years and male were more commonly affected than female. According to Socio economic status p16 positive cases were most commonly found in Lower status. Present study also showed that most of the p16 positive patients with SCC were married and literate. In most of the p16 positive cases history of one or more predisposing factors were present. Tobacco chewing came out as a most common risk factor. Most of the p16 positive cases were located at Oropharynx that came out as most common site. In all p16 positive cases, most of them had Non Keratinizing SCC which was statistically significant.