COMPARISION OF VARIOUS DOSES OF INTRAVENOUSLY ADMINISTERED DEXMEDETOMIDINE WITH FENTANYL ON HAEMODYNAMICS TO INTUBATION IN PATIENTS UNDERGOING SURGERY UNDER GENERAL ANESTHESIA

Abstract

Background: During general anesthesia , direct laryngoscopy and intubation results in a profound sympathoadrenal response which leads to tachycardia , hypertension and in predisposed individuals may lead to myocardial ischemia and arrhythmias. Various drugs such as opioids, lignocaine, propofol, beta blockers, alpha agonists have been used to minimize these adverse responses. Methods: 90 patients ASA1, ASA2 scheduled to undergo elective and emergency surgery under general anaesthesia were enrolled in double blind prospective randomized controlled trial. ey were randomly allocated to one of the following groups. Group A received 2 micro gram/kg fentanyl intravenously10 minutes before induction. Group B received 2 micro gram/kg fentanyl and 0.5 microgram/kg dexmedetomidine intravenously 10 mins prior to induction. Group C received 2 mico gram/kg fentanyl and 1 microgram/kg dexmedetomidine i.v. 10 minutes prior to induction. Results: Both study groups(B & C) were comparable with respect to there heart rate at base line, 1 minute,2.5 minutes, 5 and 10 minutes after administration of the study drug. Group C(Dexmedetomidine 1 g) demonstrated a greater suppression of chronotropic response to intubation as compared together two groups. Both the groups (B & C) were comparable to their SBP at base line 5 and 10minutes Group C demonstrated a better suppression of the pressor response to intubation compared to other two groups