ROLE OF ALPHA-KLOTHO PROTEIN IN FIBROGENESIS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY-Reference-Cited by-同舟云学术

ROLE OF ALPHA-KLOTHO PROTEIN IN FIBROGENESIS AT DIFFERENT STAGES OF DIABETIC NEPHROPATHY

Published:2022-10-01 Issue: Volume: Page:12-14
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Kavuparambil Liji¹,Kumar Pammi Ashok²

Affiliation:

1. Assistant Professor, MES Medical College, Kerala, India.

2. Professor & HOD, Rajah Muttiah Medical College, Annamalai University, Tamil Nadu, India.

Abstract

Introduction: Alpha Klotho protein monitoring in diabetic nephropathy patients is important because the deciency appears to be a risk factor for the development and progression of diabetic nephropathy and thus has prognostic value. There is conicting evidence regarding the relationship between Alpha Klotho protein and brogenesis in diabetic nephropathy. A 2-year cross-s Methods: ectional study of 120 diabetic patients, with and without nephropathy enrolled at MES Medical College. Alpha Klotho protein and the brogenesis regulator, TGF-β1 were measured using ELISA. Results: Conclusion: In diabetic nephropathy patients, Alpha-Klotho protein had a signicant negative correlation with TGF-β1 and eGFR. Alpha-Klotho protein levels have been found to be lower in diabetic nephropathy patients and signicantly related to the severity of the disease. Alpha-KL protein also correlated signicantly with the marker of brogenesis, TGF- beta 1. So it has a value as a prognostic marker and role in preventing brogenesis in diabetic patients.

Publisher

World Wide Journals

Subject

Virology,Infectious Diseases,Microbiology (medical),Microbiology,Cardiology and Cardiovascular Medicine,General Medicine,Internal Medicine,Immunology,Immunology and Allergy,Pharmacology (medical),General Pharmacology, Toxicology and Pharmaceutics,General Medicine,Dermatology,Endocrinology, Diabetes and Metabolism,Gastroenterology,Hepatology,Hematology,Biomedical Engineering,General Medicine,Surgery,Genetics,Molecular Biology,Molecular Medicine,Pathology and Forensic Medicine

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