EVALUATION OF ANALGESIC EFFECT OF BACLOFEN IN ALBINO RATS IN COMPARISON WITH DICLOFENAC-Reference-Cited by-同舟云学术

EVALUATION OF ANALGESIC EFFECT OF BACLOFEN IN ALBINO RATS IN COMPARISON WITH DICLOFENAC

Published:2020-11-01 Issue: Volume: Page:46-47
ISSN:
Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
language:en
Short-container-title:IJAR

Author:

M. D R. Mangala Devi¹,M. D Akhil²,DNB S. Vasanth M.D³

Affiliation:

1. Assistant Professor, Institute of Pharmacology , Madurai Medical College.

2. Associate professor, Department of Pharmacology, Government Kanyakumari Medical college.

3. Assistant Professor , Department of Pharmacology , Government sivagangai medical college.

Abstract

Aim and objective: To evaluate the analgesic effect of baclofen in albino rats in comparison with diclofenac. Materials and Methods: Eighteen inbred male albino rats weighing about 150-200 gms were selected from central animal house. They were divided into three groups, with six rats in each. Group I served as control received normal feed and water. Group II served as standard received T. Diclofenac – 10 mg/kg (oral). Group III served as test group received T. Baclofen -- 8mg/kg (oral). The analgesic effect of baclofen was evaluated using Eddy’s hot plate method and tail-flick method and compared with diclofenac. The values obtained are expressed as mean ± SEM. Statistical analysis of differences between groups was carried out using one-way analysis of variance (ANOVA). Probability (P) value of <0.05 was taken as the level of statistical significance. Results: Baclofen showed statistically significant analgesic activity in comparison with control group and standard group (P < 0.05). Conclusion: Baclofen a GABA- B agonist has significant analgesic activity comparable to that of diclofenac (P < 0.05)

Publisher

World Wide Journals

Reference9 articles.

1. Terry J.Baumann, Jennifer M.Strickland, and Chris. M. Herndon. Pain management. In: Joseph T. DiPiro, Robert L. Talbert, Gary C. Yee, Gary R. Matzke, Barbara G. Wells, L. Michael Posey(eds.) Pharmacotherapy a pathophysiological approach, 8th Edition. New Delhi: McGraw Hill; 2011.p. 1045-1059.

2. Lee A. Kral and Virginia L. Ghafoor. Pain and Its management. In: Brian K. Alldredge, RobinL. Coreli, Michel E. Ernst, B. Joseph Gugliemo, Pamala A. Jacobson, Wayne A. Kradjan, Bradly R. Williams(eds.) Koda kimble & Young’s Applied Therapeutics The Clinical Use of Drugs,10thEdition. Philadelphia: Wolters Kluwer/ Lippin cott Williams and Wilkin; 2013.p.112- 146.

3. Robert S. Griffin, Clifford J. Woolf. Pharmacology of Analgesia. In: Clifford J. Woolf David E. Golan, Armen H. Tasjian Jr., Ehrin J. Armstrong, April W. Armstrong. In: Principles of Pharmacology.The Pathophysiological Basis of Drug therapy,3rd Edition. Philadelphia: Wolters Kluwer/ Lippin cott Williams and Wilkin; 2011.p.264 - 283.

4. G. Francis Britto, K.R. Subash, N. Jagan Rao, Binoy Varghese Cheriyan, S. Vijay Kumar. A Synergistic Approach to evaluate the Anti-Nociceptive Activity of a GABA Agonist with Opioids in Albino Mice. Journal of Clinical and Diagnostic Research. May, 2012; Vol 6 (4): p 682- 687.

5. Gerhard H. Fromm. Baclofen as an adjuvant analgesic. Journal of Pain and Symptom management. November, 1994; Vol 9 (8): p 500-509.