HISTOPATHOLOGICAL PROFILE OF THE ENDOMETRIUM IN PRE AND POSTMENOPAUSAL WOMEN WITH ABNORMAL UTERINE BLEEDING AT TERTIARY CARE CENTRE

Abstract

Introduction Pre and postmenopausal bleeding is one of the commonest conditions for which patients seek advice in the gynaecological outpatient department. Endometrial biopsy is the gold standard for evaluating such cases.Aims And Objectives To determine various histological pattern of endometrium in pre and post-menopausal women and to study the spectrum of lesions of the endometrium with respect to age and clinical features. Methods This is a prospective study of the histopathology prole of the endometrium among 100 cases of premenopausal(45+/-5yrs)and postmenopausal (50 yrs and above)patients with AUB symptoms and D and C /endometrial biopsy/hysterectomy done in department of Obstetrics and Gynaecology,Patna Medical College and Hospital over a period of two years which was histopathologically examined in department of pathology,Patna Medical College and Hospital. Results Maximum incidence of AUB was found in 40-50 yrs age group(53%).Menorrhagia was the commonest bleeding pattern.on histopathological examination,proliferative endometrium constitutes 36% followed by atrophic endometrium (33%).In 40-50 yrs age group proliferative endometrium (49%) followed by secretory endometrium (23%),Atrophic endometrium (15%),hyperplasia without atypia (9%),Atypical Hyperplasia(4%).In >50 yrs ,Atrophic endometrium(53%),proliferative endometrium(21%),secretory endometrium(9%),chronic endometritis(9%),hyperplasia without atypia(2%),atypical hyperplasia(2%), endometrial carcinoma type I(2%),type II(2%). Conclusion Histopathological examination of the endometrium is an inexpensive and accurate method for diagnosis of such cases.It helps to differentiate benign and malignant causes and plan further line of management of the patient.