THE EFFECTS OF GENETIC AND NON GENETIC FACTORS ON WARFARIN DOSE RESPONSE IN VENOUS THROMBOEMBOLISM-Reference-Cited by-同舟云学术

THE EFFECTS OF GENETIC AND NON GENETIC FACTORS ON WARFARIN DOSE RESPONSE IN VENOUS THROMBOEMBOLISM

Published:2021-08-01 Issue: Volume: Page:4-5
ISSN:
Container-title:INDIAN JOURNAL OF APPLIED RESEARCH
language:en
Short-container-title:IJAR

Author:

Sundari . A Bala Tripura¹,Sivaraj R.²,Pandey Sunil Kumar³

Affiliation:

1. PhD Scholar Department of Pharmacology Vinayaka Mission’s Research Foundation Deemed University, Salem. Tamil nadu- 636308

2. M.B.B.S., MD., DIH., Professor, Dept. Of Pharmacology, Aarupadai Veedu Medical College & Hospital. Kirumampakkam, Pondy To Cuddalore ECR Main Road, Pondicherry. Vinayaka Mission's Research Foundation.

3. Professor Department Of Pharmacology Gayatri Vidya Parishad Institute Of Health Care And Medical Technology Madhurawada Visakhapatnam Andhra Pradesh 530048

Abstract

BACKGROUND Warfarin is the most commonly used oral anticoagulant for the treatment and prevention of thromboembolic disorders. Pharmacogenomics studies have shown that variants in CYP2C9 and VKORC1 genes are strongly and consistently associated with warfarin dose variability. METHODOLOGY In this review, we included patients on stable warfarin dose and had the genetics and non-genetics factors associated with mean warfarin dose. We searched PubMed, Medline, Scopus, Google scholar and reference lists of relevant reviews. CONCLUSION Genetic and non-genetic factors affects the dose of warfarin. Genetic factors and Non genetic factors plays a signicant role and that may affects the dose of warfarin

Publisher

World Wide Journals

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