PREVALENCE AND ANTI MICROBIAL SUSCEPTIBILITY OF CLINICAL ISOLATES OF ENTEROCOCCUS SPECIES WITH SPECIAL REFERENCE TO VANCOMYCIN RESISTANCE

Abstract

Background: Among enterococcus species , 80 -90% and 5-10% of human infection are caused by enterococcus faecalis and faecium respectively .The rate of isolation of Enterococcus faecium and other species is increase at recent times from various clinical samples . Enterococcus faecium showing higher degree of drug resistance. Enterococcus gallinarum and Enterococcus casseliavus are intrinsically resistant to vancomycin thereby inappropriate treatment can be avoided. Materials and methods: The clinical samples included blood, urine and exudates (pus,tissues, sterile body uids) were collected aseptically and processed as per standard methods for isolation and identication of organism. Antimicrobial susceptibility testing was performed using Kirby Bauer disc diffusion method. A total of 64 Enterococcus strains were isolated from clinic Result: al samples during the study period.The maximum number of Enterococcus isolates were obtained from Exudates 37(57.8%) ,urine 23(35.9%) followed by blood 4(6.2%) .Among Enterococcus species ,E.faecalis 59 (92.2%) and E.faecium 5 (7.8%) was isolated. The isolates from urine and exudates were predominantly resistance to antimicrobials like ampicillin, high level aminoglycoside, ciprooxacin and sensitive to linezolid, vancomycin and nitrofurantoin for urine samples. Enterococcus faecalis isolates were uniformly sensitive to Ampicillin, Gentamicin, Ciprooxacin, Linezolid and Vancomycin. Enterococcus faecium isolates were sensitive to Linezolid and Vancomycin and resistant to Ampicillin, Gentamicin, Ciprooxacin. Conclusion: This study illustrates the prevalence and antibiotic susceptibility pattern of enterococcus species from various clinical samples . In our study Enterococci did not show resistant to vancomycin.