IMMUNOHISTOCHEMISTRY BASED CHARACTERIZATION OF NON- SMALL CELL LUNG CARCINOMA IN A TERTIARY CARE CENTRE OF EASTERN INDIA.-Reference-Cited by-同舟云学术

IMMUNOHISTOCHEMISTRY BASED CHARACTERIZATION OF NON- SMALL CELL LUNG CARCINOMA IN A TERTIARY CARE CENTRE OF EASTERN INDIA.

Published:2022-04-01 Issue: Volume: Page:56-58
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Ranjan Alok¹,Khanna Nisha²,Ranjan Vivek³

Affiliation:

1. MD, DM, Assistant Professor, Department of Medical Oncology, Indira Gandhi institute of Medical Sciences, Patna, Bihar- 800014.

2. MD, Senior Resident, Department of Pathology,All India institute of medical sciences.

3. MD, Senior Resident, Department of Anaesthesiology, All India institute of medical sciences, Patna, Bihar - 801507.

Abstract

NTRODUCTION- Lung malignancies are the leading cause of cancer-related mortality in industrialized countries. Lung malignancies are traditionally classied as Non-Small Cell Lung Carcinoma(NSCLC) and Small Cell Lung Carcinoma. The NSCLCs are the most common type and is further subclassied into adenocarcinoma, squamous cell carcinoma, and large cell carcinoma. This is aMATERIAL AND METHODS- cross-sectional study done between 2019 and 2021 at the tertiary cancer centre at Jharkhand. A total of 100 diagnosed cases of Non-small cell lung cancer by histopathological examination of lung biopsy are included in this study. Followed by immunohistochemistry with p63, TTF-1, Napsin A, and CK 5/6. Out of 100 cases, 60 cases were of adenocarcinoma and 40 cases of squamous cell carcinoma. Among those 60 cases ofRESULTS- adenocarcinoma, NapsinAwas positive in 85% cases and TTF-1 was positive in 93% cases, CK5/6 and p63 positivity was seen in 7 % and 8% cases respectively. Out of 40 cases of squamous cell carcinoma, 92% cases were immunoreactive for CK5/6 while p63 was positive in 85% cases, 25% cases were also positive for TTF-1. In our study, Napsin A was more specic than TTF-1 regarding the diagnosis of lungDISCUSSION- adenocarcinoma, and CK5/6, having more specicity than p63, showed signicant immunoreactivity with regards to lung squamous cell carcinoma.

Publisher

World Wide Journals

Reference24 articles.

1. Charles S. Dela Cruz, MD, Ph.D., Lynn T. Tanoue, MD, and Richard A. Matthay, MD. Lung Cancer: Epidemiology, Etiology, and Prevention.2011 December;32(4):10.1016

2. V Noronha, R Dikshit, N Rautet al. Epidemiology of lung cancer in India: Focus on the differences between non-smokers and smokers: A single-center experience.2012;vol 49:page 74-81

3. William D Travis, Elisabeth Brambilla, Allen P. Burke et al . WHO classification of tumors of the lung, heart, pleura, thymus and heart,4th edition. IARC.2015

4. Lazzaro D, Price M, De Felice M, Di Lauro R. The transcription factorTTF-1is expressed at the onset of thyroid and lung morphogenesis and in restricted regions of the fetal brain. Development 1991;113: 1093-104.

5. Musti AM, Ursini VM, Avvedimento EV, Zimarino R, Di Lauro RA cell-type-specific factor recognizes the rat thyroglobulin promoter. Nucleic Acids Res 1987; 15: 8149-66.