PATTERNS OF FAILURE AND SURVIVAL IN ER/PR POSITIVE CARCINOMA BREAST WITH CONVENTIONAL VERSUS EXTENDED HORMONAL THERAPY.

Abstract

Breast cancer is the second most common cancer in the world. Globally over the last several decades, the incidence of breast cancer has increased and the greatest increase has been seen in Asian countries and women in their 40s are affected mostly. Adjuvant Endocrine therapy is highly effective and appropriate for nearly all women with Estrogen Receptor- and/or Progesterone positive tumors, making such treatment the most widely prescribed therapy for patients with cancer in both the developed and developing countries. The present study aimed to compare the pattern of failure and survival in Estrogen Receptor/Progesterone Receptor positive Carcinoma Breast with conventional i.e. patients who have received hormonal therapy for 5 years versus extended hormonal therapy i.e patients who have received hormonal therapy for more than 5 years. Assessing short & long term effects prole of these hormonal regime. The present retro-prospective study was conducted in a multidisciplinary Tertiary care hospital in Srinagar, over a period of 2 years (August 2016 to August 2018) and a total of 105 patients were included in the study. It was observed in the study that mean age of study participants was 46.5±8.55 years in group A, and 43.2±7.31 years in group B and majority (40.95%) of the participants were in the age group 40-49 years. In Group- A, 23 patients belonged to Urban and 28 belonged to Rural whereas in Group-B, 38 subjects belonged to Urban areas and 16 from rural area. It was concluded in the study that patients who are on extended hormonal therapy had overall high survival 5.71% in comparison to conventional therapy i.e., 1.96%.