EPIDURAL ROPIVACAINE: EFFECTS OF HIGH-VOLUME/ LOW-CONCENTRATION VERSUS LOW-VOLUME/ HIGH-CONCENTRATION IN RENAL TRANSPLANT PATIENTS

Author:

Kanwar Manjit Singh1,Guleria Aryan2,Ahluwalia Bhawna3,Singha Dheeraj4,K. Arya Virendra5

Affiliation:

1. Assistant Professor, Anesthesiology, Dr Radhakrishnan Government Medical College, Hamirpur, HP.

2. MBBS, MD, MO Anaesthesia, CH Palampur

3. MBBS, DA, DNB, Senior Resident, Anesthesiology, Dr Radhakrishnan Government Medical College, Hamirpur, HP.

4. MBBS, DNB, Associate Professor, Anesthesiology, Dr Rajendra Prasad Government Medical College, Kangra At Tanda, HP.

5. MBBS, MD, FRCPC, Professor Anesthesiology, Max Rady College of Medicine, University of Manitoba, Department of Anesthesiology, Preoperative and Pain Medicine, SBGH, Winnipeg, MB, Canada.

Abstract

Background: Choice of an appropriate analgesic regimen is especially important in ESRD patients. Regional analgesia technique such as epidural with local anaesthetic drugs has been found suitable in such patients. This study was designed to compare a high-volume/low-concentration with low-volume/high concentration ropivacaine regimen in ESRD transplant patients. Materials And Methods: This prospective, open level randomized control study was conducted on 40 end stage renal disease (ESRD) patients, aged between 20- 60 years of either sex who underwent live-related renal transplant surgery.GROUP A Low volume/High concentration group received 6 ml of 0.75% ropivacaine and GROUP B High volume/Low concentration group received 12 ml of 0.375% ropivacaine.Total dose of ropivacaine needed for postoperative pain control and for achieving T6 to S5 sensory block, Level of motor blockade and Dose of vasopressors needed for haemodynamic stability was compared. Results: Total dose of ropivacaine required to achieve T6 to S5 sensory block and total dose of vasopressor used was higher in low volume high concentration group at initiation of block. Postoperative quality of analgesia as assessed by VAS score and top up requirements (total dose of postoperative ropivacaine used) was comparable in both the groups. Conclusion: We conclude no added advantage of using low volume high concentration ropivacaine drug regimen in renal transplant recipients in terms of quality of analgesia and haemodynamic stability.

Publisher

World Wide Journals

Reference22 articles.

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2. Converse RL, Jacobsen TN, Toto RD, Jost CM, Cosineto F, Fouad-Tarazi. Sympathetic overactivity in patients with chronic renal failure. N England J Med 1992; 327: 1912-18.

3. Rockemann G, Seeling W, Pressler S, Steffen P, Georgiff M. Reduced postoperative analgesic demand after inhaled anaesthesia in comparison to combined epidural- inhaled anaesthesia in patients undergoing abdominal surgery. Anesth Analg 1997; 84: 600-5.

4. Davies J, Silbert S, Mooney J, Dysart H, Meads C. Combined epidural and general anaesthesia versus general anaesthesia for abdominal aortic surgery. Anaesth Int Care 1993; 21: 790-94.

5. Kida H, Nishikawa N, Matsunami K, Katsuyama R, Kawahito M. The effect of epidural anaesthesia on reducing blood loss during upper abdominal surgery. Masui 1999; 48: 265-70.

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