TO COMPARE THE EFFICACY OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE IN SHORTENING OF THE FIRST STAGE OF LABOUR AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR-Reference-Cited by-同舟云学术

TO COMPARE THE EFFICACY OF DROTAVERINE HYDROCHLORIDE AND VALETHAMATE BROMIDE IN SHORTENING OF THE FIRST STAGE OF LABOUR AT OBSTETRICS AND GYNAECOLOGY DEPARTMENT OF JLNMCH, BHAGALPUR, BIHAR

Published:2021-02-01 Issue: Volume: Page:80-82
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Jha Archana¹,Kumar Satyendra²,Kumari [Prof.] Usha³,Jana Debarshi⁴

Affiliation:

1. Associate Professor, Department Of Obstetrics And Gynaecology, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar.

2. Assistant Professor, Department Of Pathology, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar.

3. Professor And Head Of Department, Department Of Obstetrics And Gynaecology, Jawaharlal Nehru Medical College & Hospital, Bhagalpur, Bihar

4. Young Scientist (DST), Institute Of Post-Graduate Medical Education And Research, A.J.C. Bose Road, Kolkata-700020, West Bengal, India.

Abstract

Background: To compare the efcacy of Drotaverine Hydrochloride and Valethamate Bromide in shortening of the rst stage of Labor. Drotaverine is more effective in regards of shorten the 1st stage of labor, rate of cervical dilatation with less side effects in compare to Valethamate Bromide. Methods:Two Hundred demographically similes woman with full term pregnancy in active labour were included in the study and divided into two groups viz. First Group: 100 women were given injection Drotaverine Hydrochloride (Drotin) 40 mg intramuscularly at 3-4 cm dilation at two hour interval. Second Group: 100 women were given injection Valethamate Bromide Intramuscularly at 3-4 cm dilation at one hour interval. Maximum three injections were given in both the groups. Comparative analysis was carried out as regards to duration of various stages of labor, rate of cervical dilatation, mode of delivery, side effects and feto-maternal outcome. Results: In Group-I Average duration of active phase of rst stage of labor was 149.78 minutes. In Primigravida it was 170.22 minutes and 129.35 minutes in Multigravida. In Group II Average duration of active phase of rst stage of labor was 294.62 minutes. In Primigravida it was 321.71 minutes and 267.54 minutes in Multigravida. Average rate of cervical dilatation in Group-I was 2.81cm/hour. In Primigravida it was 2.50 cm/hour while in Multi gravid it was 3.33cm/hour. In Group-II average rate was 1.42 cm/hour, in Primigravida it was 1.30 cm/hour and in Multigravida1.57 cm/hour. Conclusions: Drotaverine signicantly shorten the duration of rst stage of labor and found to be safe with no adverse effect on the mother and fetus.

Publisher

World Wide Journals

Reference12 articles.

1. Anju H, Khosla I, Dahiya K. A comparative study of Valethamide Bromide with Drotaverine in normal labor. I obstet gynecol Ind. 2003;53:568-70.

2. Blasko G. pharmacology, mechanism of action and clinical significant of a convenient antispasmodic agent: Drtaverine. JAMA India. 2001;4:55-6.

3. Jayashree S, Virupaksha A, Sujatha M. Comparison of drotaverine and valethamate bromide in first stage of labor. Int J Biol Med Res. 2013;4(2):3215-8.

4. Kaur D, Kaur R. Comparision of Drotaverine and Epidosin in first stage of labor. J obstet gynecol Ind. 2003;53:449-53.

5. Malay S, Bejoylakshmi G, Biswas B. A study of Drotaverine on duration of first stage of Labor.JIMSA. 2000;13(4):256-7.