Correlation between Thyroid Hormones and Thyroid Stimulating Hormone with Lipid Profile Parameters in Euthyroid Patients

Abstract

Background: Thyroid function regulates wide ranges metabolic parameters, the most striking action being an increase in energy expenditure. Thyroid function significantly affects lipoprotein metabolism, thus influencing overall CVD risk factors. Hyperthyroidism occurs due to hyper secretion of thyroid hormones. Hypothyroidism is a clinical condition where there is hypo secretion of thyroid hormones. This is usually due to thyroid failure but can also be due to disease of the pituitary or hypothalamus. Materials and Methods: A cross-sectional study was conducted in the Department of Biochemistry, Index Medical College Hospital and Research Centre from July 2018 to January 2020. Total 114 patients were enrolled of group age between 21 to 80 yrs . Lipid profile and thyroid profile were estimated and their values were compared. Result : TSH significantly negative correlated with fT3 (-0.277, p<0.05) fT4 (r=-0.290, p<0.05) and statistically positive correlation with TC (r=0.277, p<0.05) and LDL-C (r=0.278, p<0.05. fT3 was positively correlated with LDL-C (-0.373, p<0.01) Conclusion: Thyroid dysfunction especially hypothyroidism was more prevalent among women.. Thyroid dysfunction is associated with the altered lipid metabolisms responsible for cardiovascular diseases. Therapeutic measures to control thyroid disorders could be beneficial for the better regulation of dyslipidemia and its complications.