STUDY OF HER2 NEU POSITIVITY IN GASTROINTESTINAL CANCERS AT A TERTIARY CARE HOSPITAL IN INDIA

Abstract

Introduction- HER2 is now well recognized as a key factor in the development of certain solid human tumors .The expression of Her2/ Neu in gastrointestinal malignancies is new concept with paucity of literature. Aim- The present study was conducted in a tertiary care cancer hospital in India to evaluate Clinicopathological features in resected cases of gastrointestinal cancer cases and their correlation with Her2/Neu expression by Immunohistochemistry. Material & Methods- The present study was carried out in department of pathology at regional cancer tertiary centre from October 2017 to October 2019. The cases were selected on basis of inclusion & exclusion criteria.Her2/Neu expression was assessed in all 100 cases. Results- In present study HER2/neu status was determined on 100 cases by immune histochemistry and all IHC 3+ are accepted as HER2/neu positive cases, 2+ were equivocal and 1+/0 were negative. Out of 100 cases, 8 cases (8%) show HER2/neu 3+, 5 cases were HER2/neu 2+, 20 cases showed HER2/neu 1+ score and 67 cases showed Her2 Neu score 0. The mean age of all tumors was 53.7year (Standard Deviation 14.08 ) (P =0.59). Mean age of gastric and GEJ cancer 57.1 year (SD-12.01), small intestine cancer 57.7 year (SD-7.41), pancreatobiliary cancer 55.50 year (SD-14.86),colon cancer 54.5 year (SD-13.94),rectal cancer 52.1 year (SD- 15.45).Out of 100 cases , 59 cases were male and 41 were female (M:F= 1.4:1In the GIT tumors no statistically signicant association was found between her2/ neu status with histological type , T stage , size of tumor , grade and TNM stage . The only signicant association of Her/ 2 Neu was found with Modied Astler coller staging. Conclusion- Modied Astler Coller stage can be used as screening test for centers where facility of Her2neu test not available.