ORAL CLONIDINE AND ANAESTHESIA: EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC CHANGES DURING LAPAROSCOPIC CHOLECYSTECTOMY-Reference-Cited by-同舟云学术

ORAL CLONIDINE AND ANAESTHESIA: EFFECT OF ORAL CLONIDINE PREMEDICATION ON HEMODYNAMIC CHANGES DURING LAPAROSCOPIC CHOLECYSTECTOMY

Published:2021-01-01 Issue: Volume: Page:1-3
ISSN:
Container-title:INTERNATIONAL JOURNAL OF SCIENTIFIC RESEARCH
language:en
Short-container-title:ijsr

Author:

Thakur Shyam Kishor¹,Jha Satyeshwar²,Jana Debarshi³

Affiliation:

1. MBBS, M.D. (Anaes.), Assistant Professor, Department of Anaesthesiology and Critical Care, Darbhanga Medical College and Hospital, Laheriasarai, Bihar.

2. D.A., M.D. (Anaes.), Associate Professor and Head of Department, Department of Anaesthesiology and Critical Care, Darbhanga Medical College and Hospital, Laheriasarai, Bihar

3. Young Scientist (DST), Institute of Post-Graduate Medical Education and Research, A.J.C. Bose Road, Kolkata, West Bengal, India-700020.

Abstract

Background: Laryngoscopy and intubation are mandatory for patients undergoing general anesthesia. Direct laryngoscopy and intubation along with pneumoperitoneum with carbon dioxide (CO2) insufflation for laparoscopic surgery cause afferent sympatho-adrenal response, this causes increase in blood pressure (BP), heart rate (HR) and cardiac arrhythmias in some patients Oral Clonidine premedication has been recently shown to have a potential to prevent such harmful responses. Aim: To evaluate the efficacy of administration of oral Clonidine premedication to attenuate hemodynamic responses due to laryngoscopy, intubation and pneumoperitoneum during laparoscopic surgery. Methods: After taking informed consent, 200 patients were systematically randomised into two groups of 100 each. Patients were kept NPO 8 hours, after proper preanesthetic checkup before surgery. On morning of surgery Group C received Oral Clonidine150mcg premedication 90 minutes prior to induction in the preoperative room and Group P ,oral ranitidine150mg (Pacebo) premedication 90 minutes before shifting the patient immediately afterwards to the operation room. Results: Oral Clonidine premedication in a dose of 150 mcg orally before laryngoscopy and intubation effectively attenuates hemodynamic responses during intubation and pneumoperitoneum during elective laparoscopic cholecystectomy. Conclusion: Oral Clonidine150mcg premedication effectively attenuates hemodynamic responses during intubation and pneumoperitoneum during laparoscopic cholecystectomy.

Publisher

World Wide Journals

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