POLYCAPROLACTONE NANOPARTICLES AS DELIVERY VEHICLE IN COMBATING DISEASES

Abstract

Conventional chemotherapy against various diseases causes severe side effects in the biological system. To overcome drug toxicity, insolubility and resistance, and to get greater therapeutic efcacies, vesicular biodegradable and biocompatible polymeric nanoparticles have attracted attention as drug delivery vehicle. Polycaprolactone (PCL) nanoparticles owing to their nanosizes, spherical shapes and easy surface functionalization capability with drug encapsulation characteristics are utilized as drug carrier for targeted biomedical applications. This review is mainly focused on the preparation of polycaprolactone nanoparticles with their surface functionalization and their usages in different targeted drug delivery applications.