COMPARISON OF PROPOFOL-NALBUPHINE AND PROPOFOL –FENTANYL COMBINATIONS IN TOTAL INTRAVENOUS ANAESTHESIA-Reference-Cited by-同舟云学术

COMPARISON OF PROPOFOL-NALBUPHINE AND PROPOFOL –FENTANYL COMBINATIONS IN TOTAL INTRAVENOUS ANAESTHESIA

Published:2020-11-15 Issue: Volume: Page:1-3
ISSN:
Container-title:GLOBAL JOURNAL FOR RESEARCH ANALYSIS
language:en
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Author:

Kishnani Kanhaiya Lal¹,Singh Satyajeet²,Dave Sanjay. P.³

Affiliation:

1. Associate Professor,Department of Anaesthesiology, Peoples College of Medical Sciences and Research Centre, Bhanpur Bhopal.

2. Junior Resident, Department of Anaesthesiology, Peoples College of Medical Sciences and Research Centre, Bhanpur Bhopal.

3. Professor and HOD, Department of Anaesthesiology, Peoples College of Medical Sciences and Research Centre, Bhanpur Bhopal.

Abstract

Introduction: Use of Total Intravenous Anaesthesia (TIVA) has increased in recent past. It has become method of choice in Day Care Surgery practice. G.A. with inhalational agents requires specific vaporizers for different inhalational agents. These vaporisers require costly periodic maintenance and calibration. Material and Methods Total 100 patients between age of 30 and 65 years belonging to ASA grade I and II under- going surgery up to 90 min duration were included. The patients were divided into two groups each of 50 patients. Patients in group A received Nalbuphine 0.2mg/Kg body weight IV and patients in group B received Inj. Fentanyl 2μg/Kg body weight IV, 5 min before induction. Patients were induced with Propofol 2mg/ kg body weight and Inj. Vecuronium 0.1mg/kg body weight. All patients were intubated. Maintenance of Anaesthesia was done with Propofol infusion. Patients were ventilated with controlled ventilation, breathing circuit attached to circle absorber. Vital parameters were monitored. Residual neuro-muscular paralysis was reversed with Inj. Neostigmine and Inj. Glycopyrolate intravenously. Results Initially reduction was observed in pulse rate and blood pressure in both groups followed by elevation. Rise from basic level was similar in both groups. Subsequent rise was more in Fentanyl group throughout the procedure while it came down to near base level in Nalbuphine group. At the end of procedure elevation of SBP and DBP was seen more in Fentanyl group. The First rescue analgesic requirement was earlier in Fentanyl group. Nausea, Shivering, Respiratory Depression and Sedation were more in Fentanyl group in postoperative period. Conclusion Nalbuphine provided comparatively better hemodynamic stability and excellent post operative analgesia. Nausea, vomiting and sedation were less with Nalbuphine. The induction was found to be smooth in both groups. Recovery from anaesthesia was early in Nalbuphine group.

Publisher

World Wide Journals

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