STUDY OF SERUM GHRELIN IN THYROID PATIENTS

Abstract

Background: Hypothyroidism is a common endocrine disorder resulting from deciency of thyroid hormone. Hyperthyroidism is a set of disorders that involve excess synthesis and secretion of thyroid hormone by the thyroid gland. Ghrelin is octanoylated peptide containing a 28 amino acid act as an energy balance regulator & play an important role in metabolic process .The aim of the study was to establish possible relationship between them. Materials and methods: The present study is a cross sectional study, was conducted in the Department of Biochemistry, J.L.N. Medical college and associated group of Hospitals, Ajmer (Raj.). 65 hypothyroid subjects (group-II) and 65 hyperthyroid subjects (group-III) attending Medical OPD of J.L.N. Hospitals were included and 130 age-sex matched euthyroid controls (group-I) were selected. Results: In hypothyroid subjects, mean serum Ghrelin levels were found to be signicantly higher in comparison to healthy subjects (p<0.0001). In hyperthyroid subjects, mean serum Ghrelin levels were found to be signicantly lower in comparison to healthy subjects (p<0.0001). Conclusion: The overall ndings of the present study thus conrm that serum Ghrelin level is signicantly higher in Hypothyroid subjects and the level is signicantly lower in the Hyperthyroid subjects, thus we have found positive association between serum TSH level and Ghrelin level. However, further experimental and observational studies are needed to illustrate the role of Ghrelin in Hypothyroidism and Hyperthyroidism.