Affiliation:
1. MD (Pediatrics), DM (Neonatology).
Abstract
A prompt diagnosis of neonatal hypoxic-ischemic encephalopathy (HIE) remains a clinical challenge. This study aimed at
exploring the potential of Serum protein S100B as a biomarker for evaluating neonatal HIE in newborns with moderateto-severe hypoxic-ischemic encephalopathy. Blood samples were collected from neonates with mild, moderate, or severe HIE who were admitted
to the Department of Neonatology, Madras Medical College (MMC), Chennai between September 2016 to March 2017. The plasma levels of
S100 B protein were measured at different time points. Additionally, Neurodevelopmental outcomes were also studied using MRI in surviving
infants (> 2 weeks). Eighty-four neonates enrolled in the study had moderate (n = 37), severe (n = 13) and mild HIE (n= 36). At birth, serum protein
S100 B increased with the severity of HIE (P < .001), and remained elevated in neonates with moderate to severe HIE. Serum protein S100 B was
greater up to 72 hours in moderate to severe vs mild HIE. The Elevated levels of S100B were associated with increased brain injury as studied by
MRI. The study suggests S S100 B may serve as a potential biomarker for neonatal mild HIE (n=36), moderate (n=37) and severe (n=13) could be
used for stratication at birth as elevated levels are correlated with the severity of HIE.
Subject
Public Administration,Sociology and Political Science,Public Health, Environmental and Occupational Health,Rehabilitation,Physical Therapy, Sports Therapy and Rehabilitation,Family Practice,Public Health, Environmental and Occupational Health,Sociology and Political Science,Soil Science,Environmental Chemistry,Statistics and Probability,Mechanical Engineering,Mechanics of Materials,Civil and Structural Engineering,Literature and Literary Theory,Linguistics and Language,Language and Linguistics,Pulmonary and Respiratory Medicine,Physiology