PRELIMINARY STUDY OF SERUM TRIACYLGLYCEROLAND LIPASE ACTIVITY IN NEPHROTIC SYNDROME

Abstract

OBJECTIVE - To study serum triacylglycerol level and serum lipase activity by estimating these parameters in fasting and post prandial state that is 4 hours after meal in nephrotic syndrome patients and comparing these values with the control group. Methods - Patients attending outpatient Department of LokmanyaTilak Municipal General Hospital clinically diagnosed as patients suffering from nephrotic syndrome were enrolled for the study. Duly signed consent forms were taken. Patients suffering from pancreatitis or any other acute diseases were excluded from our study. Control group comprised of age matched subjects not suffering from nephrotic syndrome or any other acute diseases. The study protocol was approved by the Ethical Committee. Results - The nephrotic syndrome group had significantly high mean serum triacylglycerol level and low lipase activity in fasting and post-prandial state that is 4 hours after meal as compared to healthy control group. Conclusion - In Nephrotic syndrome patients, hyperlipidemia and low lipase activity may accelerate atherosclerosis and progression of renal disease.