ANALYSIS OF RENAL FUNCTION IN A STUDY TO DETERMINE THE PREVALENCE OF SUBCLINICAL HYPOTHYROIDISM IN TYPE 2 DIABETES MELLITUS

Abstract

Background and Objectives - Diabetes and hypothyroidism are common endocrine diseases that impact health and mortality. Glycaemic status affects thyroid hormone levels immensely. There is a paucity of studies from India that have investigated the prevalence of subclinical hypothyroidism in patients with type 2 diabetes mellitus. In this study, we determined the prevalence of subclinical hypothyroidism in type two diabetes mellitus patients. Renal function is affected both by thyroid hormones and glycemic status, hence we have analysed renal function in the study subjects. Our study was conducted in the Department of Medicine of North D Methods - elhi Medical College & Hindu Rao Hospital, Delhi. A total of 150 patients with type 2 diabetes were screened for thyroid dysfunction, a group of 126 patients with normal thyroid function, 13 patients with subclinical hypothyroidism, and 11 patients with overt hypothyroidism were subjected to the renal function tests. 126 (84%) Results – patients out of 150 were classied as euthyroid. 11(7.3%) and 13 (8.7%) patients had overt hypothyroidism and subclinical hypothyroidism respectively. Serum creatinine value was within the normal range in 90.4% of the euthyroid diabetics. However, only 69.2% of patients with SCHT had normal serum creatinine levels. There was a signicant difference between the eGFR in euthyroid and the SCHT group, with mean eGFR in the euthyroid group being 78.26± 17.9mL/min/1.73m2 and 57.92± 27.4mL/min/1.73m2 in the SCHT group. The i Conclusion - ncidence of subclinical hypothyroidism in patients with type 2 diabetes mellitus was signicantly increased with increasing age and in female patients. Type 2 diabetic patients with subclinical hypothyroidism have increased incedence of renal dysfunction