“EFFECT ON HEMODYNAMIC RESPONSE TO LARYNGOSCOPY AND TRACHIAL INTUBATION AND THEIR ATTENUATION BY BOLUS ADMINISTRATION OF DEXMEDETOMIDINE”

Abstract

Background and Aims- Laryngoscopic and endotracheal intubation are noxious stimuli causes tachycardia, arrhythmias and hypertension. The aim of this study was to compare dexmedetomidine with placebo to attenuate stress response during laryngoscopy and endotracheal intubation.Methods-It was a randomised, double-blind placebo-controlled study. After Institutional Ethical Committee clearance, 60 patients of ASA 1& 2 were enrolled and divided into 30 each. Group NS received normal saline and Group D received injection dexmedetomidine 1μg/kgas infusion over 10 min. The general anaesthesia technique was standardised for both groups. The primary outcome measures were haemodynamic response at 1, 2, 5 and 10 min after intubation. The secondary outcome measures were to note down any adverse effects associated with drugs. The statistical package used was SPSS version 15.Results- There was a statistically significant difference (P <0.05) between Group D and Group NS in heart rate, systolic, diastolic and mean arterial pressures after tracheal intubation with dexmedetomidine. Sedation scores were more with dexmedetomidine. None of the patients had any adverse effects. Conclusion-Dexmedetomidine 1 µg/kg as premedication can be used safely and effectively to attenuate hemodynamic response to laryngoscopy and endotracheal intubation.