A STUDY OF PLATELET VOLUME PARAMETERS IN THROMBOCYTOPENIA CASES.

Abstract

Recent studies showed that platelet parameters such as mean platelet volume (MPV), plateletcrit (PCT), platelet size deviation width (PDW) could be used for differential diagnosis of thrombocytopenia. In the present study, accordingly, we aimed to investigate the signicance of these parameters in the differential diagnosis of thrombocytopenia. One hundred sixty-four (164) patients with thrombocytopenia were included in the present study. The patients were divided into two groups according to the time of the diagnosis of thrombocytopenia: hyperdestructive (75 ITP) and hypoproductive (25 AA, 25 MDS, 24 AML, 15 ALL). The diagnosis was made based on hematological, pathological, and chromosomal analyses and guidelines. Samples for complete blood counts were collected in K3EDTA tubes and analyzed with an automated hematology analyzer, Beckman-Coulter. The platelet count was similar in both groups. The present results showed that there were no statistically signicant differences between the groups in terms of age, gender and PDW. However, MPV was signicantly higher in the hyperdestructive group than the hypoproductive group. By contrast, PCT was considerably lower in the hyperdestructive group than the hypoproductive group The results of the present study indicated that these platelet parameters might provide additional contributions to strengthen the diagnosis in patients diagnosed with ITPand would be benecial to consider the thrombocyte parameters as well as the clinical and other laboratory tests of the patient