CARDIOVASCULAR POTENTIAL OF THE BARKS OF TRUNK OF BUCHHOLZIA CORIACEA (CAPPARIDACEAE) AT THE ALBINO MALE RAT

Abstract

Buchholzia coriacea is a plant of the Congolese pharmacopeia. Her barks of trunk were the subject of aphrodisiac study in our laboratory. But her effect on the arterial pressure, the cardiac frequency and on the contractions of the heart, remain even unknown. This is how the present work aims the assessment of the cardiovascular potential of the barks of trunk of this plant at the albino male rat. The effects on the mean arterial pressure and the cardiac frequency at the rat normotended have been valued by the method invasive whereas the classic model of drip of isolated heart of batrachian has been used to value the effects on the heart isolated of toad. The administration of the aqueous extract of the barks of trunk of B. coriacea (10, 20 and 40 mg/kg, i.v) decreases the mean arterial pressure and the cardiac frequency as the yohimbine(1mg/kg, i.v) and the µg acetylcholine (50 µg / Kg, i.v).This effects hypotensor and negative chronotrope are raised completely by the atropine (1 mg / kg. i.v), ce that conrms the implication of the receiving muscarinics in the mechanism of action of this extract. To the concentrations of 2; 2,5 and 3 mg / ml extracts it aqueous of the barks of trunk of B. coriacea decreases strength and the frequency of the contractions of the heart isolated of toad and to 4 and 5 mg/ml, it drags to a reversible stop of the contractions of the heart isolated of toad.