INTERPLAY OF HORMONAL PARAMETERS & IL – 6: OBESE VS NON-OBESE PCOS

Abstract

Background: Polycystic Ovary Syndrome, the most common endocrinological disorder among women in the reproductive age group which is characterized by chronic ovulatory dysfunction, certain hormonal disturbances as well as metabolic derangements. Aim: This study aimed to see a correlation between Luteinizing Hormone and Interleukine – 6 level in normal and high body mass index women with PCOS and to establish the importance of IL – 6 as a useful biomarker for predicting detrimental consequences of PCOS like the development of type 2 diabetes mellitus. Methods: Follicle stimulating hormone, Luteinizing hormone, Thyroid stimulating hormone and Interleukine - 6 have been estimated. Statistical analysis has been performed with SPSS software. Student's T-test is used to compare means between each of the test group with the control group and Karl Pearson's method of correlation is used to nd out the correlation coefcient. Results: The study included 187 women, diagnosed with PCOS (normal BMI group: n = 25, and high BMI group: n = 31) and 100 age matched control. There were signicant association found between LH and IL – 6 concentrations in these two groups of PCOS with respect to control. Conclusion: There is an association in between IL – 6 and LH concentrations in these two groups of PCOS with respect to control. IL – 6 is a marker for T2DM and the development of T2DM does not depends on BMI. Probably, LH in its elevated condition play a vital role to develop T2DM in females with PCOS.