STUDY TO COMPARE THE EFFECTIVENESS OF POSTOPERATIVE ANALGESIA USING INTRATHECAL CLONIDINE WITH BUPIVACAINE IN INGUINAL HERNIA SURGERIES

Abstract

vBackground: For lower limb and lower abdominal surgeries, the standard anaesthetic technique is subarachnoid block. Adrenaline being the rst spinal adjuvant used to increase the duration and to reduce the toxicity of spinal anaesthesia in 1903. Many drugs have been tried in search for an ideal adjuvant. Recently it was found that use of clonidine in combination with local anaesthetic prolongs the local anaesthetic effect. Aim: To evaluate the duration of post-operative analgesia provided by two varying doses of clonidine with bupivacaine against bupivacaine alone in inguinal hernia surgeries.Materials and Method:It was a double blinded study in which patients were randomly allocated into 3. Group I received only intrathecal bupivacaine 2.5mg. Group II received bupicaine2.5mg + clonidine 30μg. Group III received bupivacaine 2.5mg + clonidine 45μg. Age of patient, Pulse rate, mean arterial pressure, Sensory and motor parameters and duration of analgesia were assessed. Results were analysed using SPSS 20.0 version and the association was tested using Chi square test. Results: The study was conducted in 90 patients with 30 patients each in Group A, B and C. Mean age was 51.6, 53.1 and 56.5 in Group A, B and C respectively. Fall is in pulse rate was more in Group III. Time taken for onset of sensory block and motor blockage was high for group C when compared to other groups with a mean period of 8.9 and 9.4 minutes respectively. The duration of motor blockade and duration of postoperative analgesia was prolonged in groups II and III compared to group I patients. On comparison with 3 groups the p value was statistically signicant for duration of motor blockage and postoperative analgesia (p value 0.001). Conclusion: Increasing the dosage of clonidine will decrease the pulse rate signicantly but Intrathecal clonidine along with bupivacaine signicantly and prolongs the duration of post-operative analgesia.