EVALUATION OF THE EFFECTS OF PHOTOTHERAPY ON VARIOUS BIOCHEMICAL PARAMETERS IN NEONATAL HYPERBILIRUBINEMIA

Abstract

BACKGROUND: Neonatal jaundice has been the most common physical nding during the earlier week of life. High values of unconjugated bilirubin can develop encephalopathy and later kernicterus. The aims of phototherapy are to avoid the occurrence of encephalopathy or kernicterus. Phototherapy has many side effects like dehydration, temperature instability, skin rashes, retinal damage, hypocalcemia, electrolyte imbalance. AIM: Aim is to investigate the effect of phototherapy in full term neonate with unconjugated hyper bilirubinemia on various biochemical parameters before and after >48 hr phototherapy. MATERIAL AND METHODS: The study was conducted in the department of pediatrics, S.P.M.C.H.I. (J.K. Lon Hospital) and hospitals attached to SMS Medical College, Jaipur, Rajasthan from June 2019 – July 2020. It was a Hospital based prospective comparative observational study. The required sample size was at least 154 Full term neonates (37 completed weeks to 42 weeks) with unconjugated Hyperbilirubinemia receiving phototherapy ≥ 48 hr. All data were collected and analyzed with the help of suitable statistical parameters. RESULTS: Present study found that all parameters ( Serum Bilirubin, Urea, Creatinine, Calcium, Total Protein, And Albumin except Serum Electrolyte) has shown similar trends i.e. statistically signicant ndings in both groups before and after phototherapy. Whereas serum electrolyte has different pattern in both groups, it showed statistically signicant results only in group-I. CONCLUSION: our study concluded that phototherapy is benecial modality with judicious calculation of the risk benet ratio.