Abstract
Background: Functional Dyspepsia is well dened when a patient had one or more of these symptoms
with duration of three months or longer like post-prandial fullness, early satiation, epigastric pain and
burning, bloating, nausea, vomiting and belching. Functional dyspepsia, consisting of epigastric pain syndrome and
postprandial distress syndrome, is a prevalent functional gastrointestinal disorder. To date, only limited treatment options are
available and conicting results in terms of efcacy have been reported. This was a prospective, com Methods: parative study
carried out for a period of six months. Patient data were extracted from their medical records. Treatment outcome was
evaluated based on the resolving of Symptoms using Gastrointestinal Symptom Rating Scale (GSRS), and (Hospital anxiety
and depression scale) HADS scales. Descriptive statistics were used to summarize patient characteristics. Unpaired t-test and
Mann Whitney test were used wherever appropriate. A total of 100 patients with conrmed funct Results: ional dyspepsia after
H. pylori eradication were included.They were randomized into two study Groups namely Group 1 & 2. Each Group consists of
50 patients. Patients in Group 1 treated with Acotiamide and Rabeprazole. Group 2 patients treated with Mosapride and
Rabeprazole. Patients with two different treatments have shown signicant improvement in gastrointestinal symptoms. The
major risk factors are consumption of junk food, tea and spicy food. Our study shows that FD is predominant in Females than
Males. Minor ADRS were reported which includes Nausea, Headache, dizziness and Constipation. study till date revealed that
effects of both gastroprokinetic drugs help in enhancing Gastric emptying Rate (GER) , Gastric Accommodation Rate (GAR)
and helps in acceleration of intestinal transit which ultimately results in preventing relaxation peristaltic movements
respectively. Our study demonstrated that Mosapride and Acotiamide were both effective and well t Conclusion: olerated in FD
patients without serious side effects. We found that effectiveness of Mosapride is 86% and Acotiamide is 84% thus Mosapride
offers good alternative to Acotiamide in treating post H.pylori FD patients. Further investigations with increased sample are
required in order to conrm the results in depth
Subject
Organizational Behavior and Human Resource Management,Applied Psychology,Ecology, Evolution, Behavior and Systematics,Sociology and Political Science,Philosophy,Religious studies,Education,Library and Information Sciences,Museology,Information Systems,History,Visual Arts and Performing Arts,History and Philosophy of Science,Health Policy,General Medicine,Issues, ethics and legal aspects,General Medicine,Organic Chemistry,Drug Discovery,Pharmacology,Management, Monitoring, Policy and Law,Nature and Landscape Conservation,Ecology,Pharmacology (medical),Drug Discovery,Pharmaceutical Science,Pharmacology